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Dehydration is a smaller but real factor too

This was designed to optimise and maintain blood levels of anti-inflammatory and antifibrotic drugs and target their action to sites of inflammation and fibrosis for the treatment of heart failure

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Delphinidin effectively upregulates p53-positively regulated pro-apoptotic genes and downregulates the expression of various anti-apoptotic genes, thereby inducing cell apoptosis (Jeong et al., 2016)

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